Central “Anorectic” Molecules |
Ingestive Effects |
Reproductive Effects |
α-melanocyte stimulating hormone (α-MSH), melanotan- II (MT-II), PT-141 |
decreases food intake in fish (Kang et al., 2011; Schjolden et al., 2009), amphibians (Carpenter and Carr, 1996), birds (Kawakami et al., 2000; Tachibana et al., 2007), and rats (Vergoni et al., 1986), and food hoarding in Siberian hamsters (Keen-Rhinehart and Bartness, 2007a; Shimizu et al., 1989) |
enhances electric organ discharge in electric fish (Markham et al., 2009), Stimulates LH secretion and sex behavior in rats (Alde and Celis, 1980; Thody et al., 1981) |
Cocaine and amphetamine-regulated transcript (CART) |
decreases food intake in fish (Volkoff et al., 2005), birds (Tachibana et al., 2003), rats (Kristensen et al., 1998) |
stimulates GnRH secretion in rats (Lebrethon et al., 2000; Parent et al., 2000) |
Cholecystokinin (CCK) |
decreases food intake in fish (Himick and Peter, 1994; Volkoff et al., 2005), birds (Tachibana et al., 2012), rats (Gibbs et al., 1973) and food hoarding in Siberian hamsters (Bailey and Dela-Fera, 1995; Figlewicz et al., 1989; Teubner and Bartness, 2010) |
stimulates GnRH and LH secretion in rats (Ichimaru et al., 2003; Kimura et al., 1983)CCK in the medial preoptic areas is required for estradiol-induced lordosis in rats (Dornan et al., 1989; Holland et al., 1997) |
Corticotropin releasing hormone (CRH) |
decreases food intake in fish (De Pedro et al., 1993; Matsuda et al., 2008), amphibians (Crespi et al., 2004), birds (Denbow et al., 1999; Furuse et al., 1997), rats (Heinrichs and Richard, 1999; Levine et al., 1983; Morley and Levine, 1982; Negri et al., 1985) and food hoarding in rats (Cabanac and Richard, 1995) reviewed by (Carr, 2002) |
inhibits spawning in fish (Mousa and Mousa, 2006), inhibits LH secretion and lordosis in rats (Olster and Ferin, 1987) and sex behavior in Syrian hamsters (Jones et al., 2002) |
Dopamine (DA) |
decreases food intake in fish (Leal et al., 2013), rats (Heffner et al., 1977), increases food hoarding in rats (Borker and Mascarenhas, 1991; Kelley and Stinus, 1985), and reward (Wise, 2004) |
inhibits gonadotropin secretion in fish (Omeljaniuk et al., 1989), stimulates sexual arousal, motivation and reward in birds (Cornil et al., 2005), rats and hamsters (Agmo and Picker, 1990; Meisel and Mullins, 2006) |
Glucagon-like peptide (GLP-I) |
decreases food intake in fish (Silverstein et al., 2001), birds (Tachibana et al., 2006), rats (Turton et al., 1996) |
stimulates LH secretion (Beak et al., 1998) |
Gonadotropin releasing hormone (GnRH I or II) |
decreases food intake in fish (Hoskins et al., 2008; Nishiguchi et al., 2012), and female musk shrews (Kauffman and Rissman, 2004b) |
stimulates LH secretion in fish (Moussavi et al., 2012), birds (Chowdhury and Yoshimura, 2004), stimulates LH secretion and sex behavior in amphibians and reptiles (Alderete et al., 1980; Licht et al., 1984), rats and sheep and sex behavior in shrews and mice (Kauffman and Rissman, 2004a; Kauffman et al., 2005) (Temple et al., 2003) (Moss and McCann, 1975) (Clarke and Cummins, 1982) |
Insulin-like Growth Factor -1 (IGF-I in CNS) |
ICV treatment decreases food intake in diabetic, but not normal rats (Lu et al., 2001), required for post-fast hyperphagia in rats (Todd et al., 2007) |
restores LH surge amplitude in middle-aged rats (Todd et al., 2010), required for the LH surge, estrous behavior, estrous cycles in rats (Etgen and Acosta-Martinez, 2003; Quesada and Etgen, 2002; Todd et al., 2007), and for sex behavior in rats (Etgen and Acosta-Martinez, 2003) |
Kisspeptin |
decreases food intake in mice (Stengel et al., 2011) |
stimulates GnRH and LH secretion in fish (Moussavi et al., 2012; Tena-Sempere et al., 2012), stimulates testicular expression of ER-a in frogs (Chianese et al., 2013), rats (Gottsch et al., 2004; Irwig et al., 2004) |
Norepinephrine |
decreases food intake in birds (Denbow, 1983) and stimulates food intake in rats (Ritter and Epstein, 1975) |
inhibits LH secretion in rats (Iwata et al., 2011), stimulates sex behavior in birds (Cornil et al., 2005) and rats (Nock and Feder, 1979) |
Oxytocin |
decreases food intake in birds (Jonaidi et al., 2003), rats (Olson et al., 1991) |
stimulates GnRH and LH secretion sex behavior in rats (Rettori et al., 1997; Whitman and Albers, 1995) |
Secretin |
decreases food intake in rats (Cheng et al., 2011a) |
stimulates LH secretion in rats (Babu and Vijayan, 1983) |
Serotonin (5HT) |
decreases food intake in birds (Denbow et al., 1982), rats (Blundell, 1977) |
stimulates LH in the presence of estradiol in rats (Coen and MacKinnon, 1979) Inhibits LH secretion in the absence of estradiol in rats (Coen et al., 1980) (Koh et al., 1984) |
Thyrotropin releasing hormone |
decreases food intake in rats (Vijayan and McCann, 1977) and Siberian hamsters (Steward et al., 2003) |
stimulates LH secretion in pituitary in vitro not in vivo in rats (Fujihara and Shiino, 1983), and indirectly by effects on thyroid hormones in rats (Barrett et al., 2007) |
Urocortin |
decreases food intake in fish, amphibians, birds, and rats (Spina et al., 1996) |
stimulates LH secretion in ewes (Holmberg et al., 2001), inhibits LH secretion in rats (Li et al., 2005; Nemoto et al., 2010), directly inhibits Leydig cell function in rats (Rivier, 2008) |